During the first decades of the 20th century and despite a centuries-old permanence, emigration, persecution and then deportation totally destroyed the ancestral Jewish community of the island of Rhodes, Greece. However, under the leadership of different players, the memory of this historical presence has shown a new vitality in the early 2000s. During this process, the last synagogue on the island, the Kahal Kadosh Shalom, has been at the very center of new practices and commemorations. It has been refurbished and transformed and it is now at the heart of a “memory complex,” engaged with local and international networks in a global dimension.