Despite statistical evidence showing that most people in Italy would prefer to die at home, less than half of deaths take place in a domestic setting, and there are significant regional differences. Based on a two-year study on palliative care in Piedmont, this paper explores the moral dimensions of “home” as the space of intimate relations and of family obligations, central to an ideal of a “good life,” and of a “good death,” too. The paper also focuses on the transformations of the domestic space once it becomes a space for care, on family tensions concerning end-of-life decisions, and on the restructuring of family networks in these situations.